Zebrafish as a model for developmental toxicity assessment
نویسندگان
چکیده
The zebrafish embryo has emerged as promising alternative model for traditional in vivo developmental toxicological screening due to their advantageous characteristics as their small size and transparency. In this paper, we reviewed the applicability of the zebrafish embryo model in some relevant areas to human toxicology as developmental toxicity, cardiovascular toxicity and neurotoxicity (behavioral assessment). Despite the promising results, further optimization and testing of more substances as well as a harmonized methodology is needed to streamline the methods and make the assay conducive to medium-throughput.
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تاریخ انتشار 2015